The purpose of this Notice is to encourage currently funded NCI extramural investigators to apply for administrative supplements to support mentored cancer research career development of early-stage low- and middle-income country (LMIC) investigators (ESLIs). The overarching goal of this supplement opportunity is to strengthen the capacity of LMIC investigators to conduct high-quality research in their LMIC home institutions to generate context-appropriate evidence to address specific cancer control priorities in LMICs.